A Brilliant Madness is the story of a mathematical genius whose career was cut short by a descent into madness. At the age of 30, John Nash, a stunningly original and famously eccentric MIT mathematician, suddenly began claiming that aliens were communicating with him and that he was a special messenger. Diagnosed with paranoid schizophrenia, Nash spent the next three decades in and out of mental hospitals, all but forgotten. During that time, a proof he had written at the age of 20 became a foundation of modern economic theory.

In 1994, as Nash began to show signs of emerging from his delusions, he was awarded a Nobel Prize in Economics. The program features interviews with John Nash, his wife Alicia, his friends and colleagues, and experts in game theory and mental illness.